ABSTRACT
Objectives: The objective of this study was to identify the association between cigarette smoking and serum bilirubin antioxidant concentrations
Study Design: A descriptive cross sectional study
Place And Duration: Study was conducted at the Department of Biochemistry at Sheikh Zayed hospital Lahore over a period of one year from January 2012 to December 2012
Methodology: The sample size was sixty with an equal distribution of healthy and control group. Thirty were known smokers and thirty were healthy controls. Thirty smokers who had been smoking for at least five pack years [20 cigarettes per day for one year is equal to one pack year] were included after ruling out coronary artery disease by Exercise Tolerance Test. Same no. of healthy control subjects were selected from general population with no history of smoking, CAD, Diabetes and hypertension
Results:The results of the study have shown that smoking decreases the serum bilirubin concentrations. The mean value of serum bilirubin in 50%[n=30] smokers was 0.59 + 0.034. While in control group 50%[n=30], it was 0.85 + 0.057
Conclusion: From the results, it was concluded that cigarette smoking lowers the bilirubin antioxidant concentration
ABSTRACT
Objectives: Objective of this study was to assess the serum bilirubin concentration [within the reference range] as a marker for coronary artery disease [CAD]
Study Design: It was a descriptive cross sectional study and simple random sampling technique was adopted for the proceedings
Place And Duration: The study was conducted in the Department of Biochemistry and Cardiology at Sheikh Zayed hospital Lahore over a period of one year
Methodology: Thirty known patients of CAD diagnosed by angiography were selected. Same numbers of healthy controls were selected
Results: The results have shown that there was a significant difference in serum bilirubin levels of both groups, when compared statistically
Conclusion: The study suggests an inverse association between serum bilirubin concentration [within the reference range] and risk of CAD and it can be used as a marker to assess predisposition towards ischemic heart disease